A computational model for how the fast afterhyperpolarization paradoxically increases gain in regularly firing neurons
نویسندگان
چکیده
منابع مشابه
Afterhyperpolarization regulates firing rate in neurons of the suprachiasmatic nucleus.
Cluster I neurons of the suprachiasmatic nucleus (SCN), which are thought to be pacemakers supporting circadian activity, fire spontaneous action potentials that are followed by a monophasic afterhyperpolarization (AHP). Using a brain slice preparation, we have found that the AHP has a shorter duration in cells firing at higher frequency, consistent with circadian modulation of the AHP. The AHP...
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متن کاملEffects of afterhyperpolarization on neuronal firing.
Stein's model for a neuron is studied. This model is modified to take into account the effects of afterhyperpolarization on the neuronal firing. The relative refractory phase, following the absolute one, is modelled by a time-increasing amplitude of postsynaptic potentials and it is also incorporated into the model. Besides the simulation of the model, some theoretical results and approximation...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2018
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00385.2017